Garcinia Cambogia: Uses, Benefits & Dosage. Scientific Name(s): Garcinia cambogia (Gaertn.) Desr. Family: Clusiaceae (Guttiferae)Common Name(s): Malabar tamarind , hydroxycitric acid ( HCA )Uses. The medical literature primarily documents weight loss and lipid- lowering activity for the plant. However, trials supporting its use are limited. Dosing. The dosages of G. The equivalent hydroxycitric acid (HCA) dose in the trials ranged from 9. Most adverse reactions included headache, dizziness, dry mouth, and GI complaints such as nausea and diarrhea. Toxicology. Toxicology studies resulted in no toxicity or deaths in animals at dosages of HCA 5,0. HCA. In patients taking certain combination weight- loss supplements containing G. The plant species has variability in its branching pattern, fruit color, shape, and size. The tree is small- to- medium in size with drooping branches. The leaves are dark green and glossy, oval- shaped with a narrow end, 5 to 1. The tree is tolerant to drought and flowers during the hot season. The yellow, orange, or red fruit ripens during the rainy season and contains HCA. It is ovoid in shape, 5 centimeters around, has 6 to 8 seeds, and is listed in the US Department of Agriculture inventory of perennial edible fruits. History. Dried fruit rinds have been used extensively for centuries throughout Southeast Asia for culinary purposes as a condiment and flavoring agent in place of tamarind or lemon. Additional culinary uses include the flavoring of curries, meat, and seafood. A series of cases show that a potential garcinia cambogia side effect might be mania, although more research needs to be done, Consumer Reports says. Garcinia Cambogia Reviews – Guidance on brands Important Criteria for evaluating Brands. No Free Trials/Subscriptions! Price Per Milligram; Label clearly shown. Garcinia Cambogia Extract Review and Full Recommendation. What is Garcinia Cambogia Extract? Garcinia Cambogia Extract is a supplement that comes from the rind of. H ow Premier Garcinia Will Effect You! So what makes this Garcinia fruit so amazing? How will this supplement help you lose weight? What more can you do to increase. We understand that your end goal is to burn fat. Plain and simple. And you want the best garcinia cambogia product to help you do that. You don't want to waste your. The fruit extract has been used as a flavoring agent for beverages and gourmet spices, as well as a carminative, thereby helping to prevent the formation of gas in the GI tract after a meal. HCA and other organic acids from the dried rind combined with salt help lower p. H and provide a bacteriostatic effect used in curing fish. The herb is considered beneficial for overall health in the traditional Ayurvedic medical system. Rheumatism and bowel complaints are treated with a decoction of the fruit rind. A rinse is used from the herbal extract in veterinary medicine for some diseases of the mouth in cattle. HCA has also become popular as an ingredient for weight loss. Chemistry. HCA is the primary medicinal component contained in the fruit rinds of G. HCA is present as up to 3. G. 6 Xanthones, xanthone derivatives, and polyisoprenylated benzophenones have been isolated. Some salts used in commercial products are water soluble and bioavailable, and are a good source of calcium (4. Studies also document interest in production of HCA by using microorganisms. Uses and Pharmacology. The medical literature primarily documents research on the weight loss and lipid- lowering activity of the plant. Dyslipidemia. In vitro and animal data. In 2 experiments using the human hepatoma cell line Hep. G2, overnight exposure to G. Flavonoids from the plant reduced lipid levels in normal and hypercholesterolemic rats. Reductions were also documented in triglycerides, phospholipids, and free fatty acids. The mechanism of action for the flavonoids may involve: (1) reducing the rate of lipogenesis by reducing the activities of lipogenic enzymes, glucose- 6- phosphate dehydrogenase, and isocitrate dehydrogenase; and (2) increasing the rate of degradation of cholesterol leading to higher levels of hepatic and fecal bile acids, as well as neutral sterols in rats treated with the herb. While dexamethasone typically elevates lipid profiles, G. Clinical data. In a 4- week randomized, double- blind, placebo- controlled trial, 1. G. Treatment groups administered the dietary supplement showed statistically significant dose- related reductions in weight, total and LDL cholesterol, and triglycerides, and improvement in high density lipoprotein cholesterol. Obesity. The suggested mechanism of action involves HCA- inhibiting lipogenesis, increasing lipid oxidation, and reducing food intake. Animal data. A study in obese rats found high doses of HCA- containing G. This same study also found testicular atrophy and toxicity at dosages of 7. HCA/kg body weight/day (1. HCA/kg diet) and higher. Another study in rats administered a high- fat diet and a mixture of G. The mixture also improved blood and hepatic lipid concentrations or the induced dyslipidemia in the rats. Other combination products with G. The antiobesity effect involves modulation of several genes associated with visceral adipogenesis. One study in adult, nonobese cats found no effect on fat- free mass or energy expenditure. Clinical data. In an 8- week randomized clinical trial, 4. G. Patients administered the extract exhibited weight loss and improvement in cholesterol and triglycerides when compared with the placebo group. In a 1. 2- week, randomized, double- blind, placebo- controlled study, 4. G. Two tablets of the supplement were taken by mouth 3 times a day after meals. The treatment group attained a 3. The majority of the active group participants did not follow the diet regimen. In a 1. 2- week, double- blind, placebo- controlled, parallel group trial, 8. G. At the end of the trial, both groups lost weight, but the treatment group achieved greater reduction in body weight. Numerous studies document the safety profile of the calcium- potassium double salt of 6. HCA preparation (HCA- SX), as well as its bioavailability and efficacy in helping patients attain a healthy body weight. An 8- week, randomized, placebo- controlled, double- blind study examined the efficacy of HCA- SX in 5. The treatment group was administered a combination supplement containing G. All patients were asked to maintain a low- fat diet and drink 6. The treatment group lost an average weight of 1. Another 8- week, randomized, placebo- controlled, double- blind study examined the efficacy of HCA in 6. The dosage regimen for HCA was 4. All patients were on a low- fat diet and also instructed to exercise 3 times a week. Results indicated weight loss for the experimental group compared with the placebo group and that 8. HCA group was because of fat loss. Appetite scores were also reduced in the HCA- treated group. Visceral, subcutaneous, and total fat accumulation were reduced in 3. The dosage regimen included HCA 1,0. At the end of the treatment, both groups were administered placebo for 4 weeks and no rebound effect was documented. Another clinical study documented that treatment with HCA failed to produce weight change and fat mass change in patients. However, the design of the clinical trial, the lack of bioavailability, and dosage of HCA used have been criticized. Other pharmacologic activity. Antioxidant. Some studies found that supplementation with G. Cancer. The fruit contains xanthones, which inhibit pre- neoplastic lesions in mammary and colon cancer. The xanthones may also induce apoptosis in mouth, leukemia, breast, gastric, and lung cancer cell lines in vitro. Diabetes. Glucose metabolism may be improved by lowering serum insulin levels in mice treated with G. Leptin is a hormone associated with appetite control. HCA treatment delayed and reduced intestinal glucose absorption in rats; the treatment causes delayed intestinal absorption of glucose rather than delayed gastric emptying. Exercise endurance. HCA promoted lipid oxidation and reduced carbohydrate use in mice at rest and during running. The utilization of respiratory gases was reduced for mice treated with HCA at rest and during exercise. Some studies on herbal coffee supplements with HCA showed an increase in resting energy expenditure to enhance metabolic rates and promote weight and fat loss. GI disorders. Antiulcer activity was observed against induced gastric mucosal injury in rats with pretreatment of G. A similar study in rats found activity against indomethacin- induced gastric ulcers. The anti- inflammatory activity of G. Red blood cell count. A G. The activity may be (1) associated with the iron in G. Dosage. The dosages of G. The equivalent HCA dose in the trials ranged from 9. G. One animal study in rats documented decreased maternal body weight gain during gestation. Interactions. Diabetic/insulin medications. In patients taking medications for diabetes by mouth or insulin, G. Iron. G. 3. 6Potassium and calcium supplements. Some commercial G. Caution is advised for patients taking medications for heart disease, high blood pressure, or arrhythmia while supplementing with any product containing this herb. Serotonin. A mouse study using a commercial polyherbal product containing G. Caution is advised for patients being treated for pain or taking medications for any psychiatric condition. Singulair (or leukotriene receptor antagonists)One case report documented fatal liver failure in a patient taking Singulair and 2 dietary supplements, one of which included G. Statins. A case report of rhabdomyolysisis is documented in a patient taking a combination herbal medicine containing G. Warfarin. In one case report, the international normalized ratio of a patient returned to normal after he stopped taking a combination herbal product containing G. Adverse Reactions. A total of 1. 5 clinical studies involving approximately 9. Most adverse reactions included headache, dizziness, dry mouth, and GI complaints such as nausea and diarrhea. Toxicology. Toxicology studies resulted in no toxicity or deaths in animals at HCA dosages of 5,0. HCA. 5 In patients taking certain combination weight- loss supplements containing G. Some animal studies document testicular toxicity, 4 , 4. No unusual electrocardiographic effects (QTc interval or other electrocardiograph variables) were seen over 5 hours in patients taking half the recommended dose of a multicomponent weight loss supplement containing G. Patients receiving G. Bibliography. 1. Abraham Z, Malik SK, Rao GE, Narayanan SL, Biju S. Collection and characterization of Malabar tamarind . Genet Resour Crop Evol . Soni MG, Burdock GA, Preuss HG, Stohs SJ, Ohia SE, Bagchi D. Safety assessment of (- )- hydroxycitric acid and Super Citri. Max, a novel calcium/potassium salt. Food Chem Toxicol . Ohia SE, Opere CA, Le. Garcinia Cambogia Extract Reviews: Everything You Should Know! Garcinia Cambogia Extract Review and Full Recommendation. What is Garcinia Cambogia Extract? Garcinia Cambogia Extract is a supplement that comes from the rind of the Garcinia Cambogia fruit (a small pumpkin- shaped fruit which is more widely known as a tamarind in many areas). The Garcinia Cambogia fruit has been around for a long, long time. People who live in regions where the Garcinia Cambogia fruit grows in its native environment have known about its health- giving benefits and have been safely enjoying them for centuries thanks to its compound called HCA or Hydroxycitric acid. Why is Garcinia Cambogia Extract Gaining in Popularity Now? The recent popularity of the Garcinia Cambogia Extract supplement can be ascribed to Dr. Julie Chen, a well- known and well- respected specialist dealing in health and wellness. Dr. Chen’s studies proved that those taking Garcinia Cambogia Extract lost two to three times more weight than those not taking the supplement. This equates to an average of ten pounds per month. What’s even more amazing is that they did this without changing their dietary habits or exercise routines. In essence, Garcinia Cambogia Extract just made the people involved in the studieslose weight while doing nothing. Clinical studies: Below you can find an abstract of some of the clinical studies made on garcinia supplements: They showed: The positive effects of the extract on reducing body weight and preventing visceral fat accumulation. Lowering critical factors such as LDL cholesterol (also called “bad cholesterol”), triglycerides and serum leptin. Increasing the levels of HDL cholesterol ( “good cholesterol”) and serotonin (strong benefits on Depression, migraine and insomnia). Garcinia was showing a good safety profile with no significant adverse effects across 8 weeks in one of the studies. How the Garcinia Cambogia Extract Works to Help You Lose Weight. The Garcinia Cambogia Extract works as a dual action fat buster. The first principle the supplement works on is suppressing your appetite. Next, it actually prevents fat from being made. This leaves the excess fat that you take in nowhere to store inside the body, meaning it passes through your system more rapidly. This means you’ll feel less hungry and in turn, take in less excess fat; you’ll only eat as much as you need. It specifically zeros in on belly fat and helps to eliminate it. This helps to balance out mood swings and alleviate the symptoms of stress and depression. Those who “stress eat” or look for solace in food will not do so as much, two of the major causes of overeating and weight gain. This shuttles all of those components directly out of your body – pushing them quickly through your digestive system and out as waste faster than you could imagine. Garcinia Cambogia is also a powerful diet suppressant and craving killer, helping you to control the portions that you eat while at the same time helping your body feel full so that you don’t snack as often as you could. Are all Garcinia Cambogia Extract Supplements the Same? Now that you can be sure that it works, there is one more thing you need to know, something we just slightly touched on. There are tons of companies that are making Garcinia Cambogia Extract supplements and putting them up for sale. There is certain qualifications you need to look for when choosing a Garcinia Cambogia Extract supplement. To find a very special offer on Pure Garcinia Cambogia, a supplement that isin- line with the recommendations and guidelinesfor choosing a Garcinia Cambogia Extract, click the link below.* Worldwide Shipping Available!
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